Microwave assisted synthesis of some 1,2,4,5-tetrasubstituted imidazole derivatives as antimicrobial agents

Imidazole derivatives have a wide spectrum of pharmacological activities especially potent antimicrobial activity against a wide variety of microbes like bacteria and fungi. Therefore, in this study new series of imidazole derivatives were synthesized and investigated for antimicrobial activity so as to obtain new biologically active compounds. Structures of the final compounds were confirmed by spectral data and elemental analyses. Final compounds, showed low antibacterial activity. However, the compounds including 1-(2-Floro or chlorobenzyl)-2-(substitutedphenyl)-4,5-Bis-(4-fluorophenyl)-1H-imidazole general structure exhibited moderate antifungal activity against Candida albicans when compared reference drug